At a secret military lab, after many years of researching a group of excellent young scientists who have just deciphered the key of invisible. The arrogant leader Sebastian Caine (Kevin Bacon) left all the dangers to test on his own body. While his colleagues were trying to find antidote, yeast was drunk about his invisible strength. And he believed that his colleagues were a threat to this invisible existence and Sebastian began to kill the research teams including Linda (Elisabeth Shue) and Matthew (Josh Brolin) to find a way to prevent Sebastian's conspiracy under the deadly chasing dead in the laboratory ...